![]() ![]() ![]() We used a swine animal model where commercial production sows were either overfed or kept under standard diet during gestation, and piglets at birth were randomly assigned to metformin ( n = 16 per group) or vehicle treatment during lactation ( n = 16 per group). ![]() In this context, our aims were: (1) to study the effects of maternal overfeeding on the metabolic and epigenetic programming of offspring’s adipose tissue and (2) to test the potential of postnatal metformin treatment to reverse these changes. Potential reversal, in early life, of these alterations may help in the prevention of future cardio-metabolic conditions. Maternal overfeeding during gestation may lead to adverse metabolic programming in the offspring mediated by epigenetic alterations. ![]()
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